Detection and Diagnostics, Technology and Market
The Promise of Ubiquitous DNA Sequencing: Sequencers as Sensors
Improvements in DNA sequencing technologies (which determine the order of the four constituent bases – A, G, C and T – in which the genetic code is written) have the potential to transform how we detect and respond to infectious disease. Defense against pathogens, whether naturally occurring diseases or intentional biological attacks, depends critically on our ability to detect and identify pathogens, in order to accurately diagnose, properly triage and treat those infected, and gauge the extent and dynamics of an outbreak. We review here the progression of DNA sequencing technologies since the 1970’s, the potential impact of sequencing on detecting and managing epidemics, and other applications that will support and expand innovations in sequencing technology.